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مقاله
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Abstract
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Title:
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The effect of intravitreal bevacizumab injection on the corneal endothelial cells : A systematic review
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Author(s):
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Samira Hassanzadeh, Akbar Derakhshan, Alireza Eslampour, Esmaeil Safinezhad
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Presentation Type:
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Poster
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Samira Hasanzadeh
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Affiliation :(optional)
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Department of Optometry, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
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E mail:
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samip2005@yahoo.com
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Phone:
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09151581572
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Mobile:
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09151581572
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Purpose:
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Bevacizumab (Avastin), as an effectiveness treatment modality, is
currently used in patients with various ocular disease. However the results have
been promising, the use of bevacizumab in the treatment of ocular disease is an
off-label application. Hence, the aim of this study was to systematically review the
effectiveness of intravitreal injection of bevacizumab on various ocular tissues,
especially corneal endothelial cells.
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Methods:
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The articles related to the effect of application of Avastin in the treatment
of ophthalmic diseases and especially its effect on corneal endothelial cells were
collected and reviewed. We searched PubMed, Google scholar, and Scopus databases
and used Avastin, ocular diseases and corneal endothelial cells as search keywords.
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Results:
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Of all 55 articles found in all databases, only 10 were relevant to the purpose
of this study, and 45 articles were excluded in several step by step process of article
selection according to the inclusion/exclusion criteria. The results revealed that
intracameral bevacizumab injection caused no changes in specular microscopy and
corneal pachymetry. Moreover, it had no significant toxicity on corneal endothelial cells.
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Conclusion:
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According to the results of included documents, bevacizumab was not
toxic to corneal endothelial cells at various clinically relevant doses.
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Attachment:
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49.pptx
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