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       XXIX Annual Congress of the Iranian Society of Ophthalmology        بـیــست و نهمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Microbiologic patterns and antibiotic sensitivity in microbial keratitis
Author(s): Mohammad Soleimani, Seyed Ali Tabatabaei, Reza Mirshahi, Bita Momenaei, Feresthe Tayebi
Presentation Type: Oral
Subject: Cornea and Anterior Segment
Others:
Presenting Author:
Name: Mohammad Soleimani
Affiliation :(optional) Tehran University of Medical Sciences
E mail: soleimani_md@yahoo.com
Phone: 88647168
Mobile: 09121096496
Purpose:

To describe causative pathogens involved in microbial keratitis and trends of microbial isolates sensitivity and resistance to routinely used ophthalmic antibiotics.

Methods:

This is a retrospective study on smear and culture samples of corneal ulcers in patients who came to Farabi eye hospital emergency ward from January 2012 to December 2018.

Results:

8912 samples were collected from patients with keratitis for 6 years, the mean age of patients with keratitis was 44.52±27.46. In patients with keratitis, 60% of cultures were negative. Pseudomonas and S.pneumonia and S.epidermidis were the most common isolates in keratitis( accounting for 10%, 5% and 4% respectively). Among patients younger than 19 years with keratitis, 41.5% were culture negative, and S.viridans was the most common isolate (13.2%) followed by S.aureus (9.5%) and S.pneumonie (8.1%). In the age group of 19-50 years, 54.3% were culture negative and Pseudomonas was the most common microorganism (15%) followed by enterobacter (7.8%) and S.epidermidis and S.aureus (4.3%). And in patients older than 50 years, 65.5% were culture negative, S.pneumonia accounted for 7.8% of isolates and pseudomonas and S.epidermidis for 6.5% and 4.8% respectively. In our study resistance of S.pneumonia to ceftazidim siginificantly increased after 2014 however other changes in antibiotic susceptibility profile was not significant.

Conclusion:

Pseudomonas and S.pneumonia and S.epidermidis were the most prevalent isolates in keratitis respectively. According to age S.viridans was the most prevalent isolate in patients younger than 19 years old with a rising trend after 2014 and Pseudomonas was the most common isolate in patients with keratitis between 19 to 50 years of age with a decreasing trend in incidence during recent years, but S.pneumonia was responsible for most of culture positive keratitis over 50 years with a decreasing trend in incidence recently.

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