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مقاله
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Abstract
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Title:
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Intravitreal Injection of Zoledronic Acid in Rat Model of Choroidal Neovascularization
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Author(s):
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Ramin Nourinia, Hamid Ahmadieh, Mozhghan Rezaei Kanavani
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Presentation Type:
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Oral
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Subject:
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Posterior Segment
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Others:
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Presenting Author:
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Name:
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Ramin Nourinia
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Affiliation :(optional)
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Ophthalmic Research Center, Shahid beheshti University Of Medical Sciences, Tehran Iran
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E mail:
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ramin.retin@gmail.com
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Phone:
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02122762086
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Mobile:
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09128249332
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Purpose:
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Purpose: To determine the effects of intravitreal zoledronic acid (IVZA) on attenuation of laser-induced choroidal neovascularization (CNV) in rats.
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Methods:
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Methods: CNV was induced in 30 pigmented rats via laser burns. Rats were divided into two groups; one group received IVZA (8 μg / 2 μL) and another group received 2 μL normal saline. Neovascularization area was detected by lectin staining of choroidal-scleral flat mounts and quantified by using Image J software.
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Results:
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Results: Mean CNV area in the IVZA group (30016.02 ± 14182.82 μm2) was less than that of the controls (43935.49 ± 31554.54 μm2) with a borderline statistical significance (P = 0.059).
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Conclusion:
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Conclusions: IVZA with dose of 8 μg / 2 μL was effective in attenuation of CNV in rats. To maximize the antiangiogenic effect of IVZA, further investigation using the maximum safe dose of IVZA should be conducted.
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Attachment:
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