o evaluate the effect of intravitreal recombinant tissue plasminogen activator (rTPA) on diabetic tractional fibrovascular membranes (FVM) using the proposed optical coherence tomography (OCT) based measurement criteria.

This prospective, interventional case series enrolled eyes that were candidates for vitrectomy. OCT images were obtained to study attached–detached retinal borders at baseline and on- week post-intravitreal rTPA injection using the follow-up scan protocols. Two independent graders assessed retinal detachment (RD) height, FVM height, FVM thickness, retinal thickness at the site of membrane attachment and release of retina-membrane touch point.

Nine eyes from nine individuals were included. Assessment of RD height, FVM height, FVM thickness and retinal thickness at touch point were feasible in 8/9 (88%), 7/9 (77%), 8/9 (88%) and 5/9 (55%) of eyes, respectively. There was an excellent agreement between the two graders in all of measurements (all ICC> 0.93). Release of retina-membrane touch point was not observed in any eyes. No statistically significant change was found in any of the measured parameters.

Our proposed OCT-based measurement system in assessing diabetic FVM was reliable and feasible. We did not find any significant change in the status of diabetic FVM, one-week after intravitreal rTPA injection, using OCT-based measurements.