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مقاله
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Abstract
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Title:
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Association Between Advanced Keratoconus and Serum Levels of Zinc, Calcium, Magnesium, Iron, Copper, and Selenium
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Author(s):
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Shahram Bamdad, Naser Owji and Alireza Bolkheir
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Alireza Bolkheir
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Affiliation :(optional)
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Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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E mail:
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soroushbolkheir@ymail.com
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Phone:
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07733534308
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Mobile:
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09173714101
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Purpose:
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To investigate the possibility of an association between
serum levels of zinc (Zn), calcium (Ca), magnesium (Mg), iron (Fe),
copper (Cu), and selenium (Se) and advanced keratoconus (KCN).
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Methods:
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In this study, 50 patients with advanced KCN and 50
control subjects were included. Plasma levels of Zn, Ca, Mg, Fe, Cu,
and Se were compared between the groups.
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Results:
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Mean ± SD age of the patients in the case and control
groups was 29.3 ± 3.5 and 28.9 ± 5.9 years, respectively (P =
0.669). Among serum parameters, there were no statistically
significant differences between the 2 groups in serum levels of Ca,
Mg, and Fe (P > 0.05), whereas serum levels of Zn and Cu were
significantly lower in the case group than the control group [65.92 ±
7.90 vs. 87.36 ± 13.64 mg/dL and 78.48 ± 11.96 vs. 116.34 ±
20.87 mg/dL, respectively (both P < 0.001)] as well as the serum
level of Se [79.76 ± 19.16 vs. 87.41 ± 15.91 mg/dL (P = 0.032)].
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Conclusion:
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The lower serum levels of Zn, Cu, and Se in patients
with advanced KCN compared with healthy controls indicate the
possible role of antioxidants in the etiopathogenesis of KCN, which
points to early treatment of this progressive degenerative disease
with supplementation therapy, rather than keratoplasty techniques.
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Attachment:
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