To determined the therapeutic effect of dorzolamide drop in Central serous chorioretinopathy among the patients referred to the eye Clinic of Vali-e-Asr hospital.

In this study, 45 patients with 33 males and 12 females with mean age were 38/64±6/39 years old. Demographic information of patients was recorded and in terms of visual acuity, eye pressure, blood tests and OCT.The patients were divided into two groups of case and control group, in case group, 26 patients and 19 patients in the control group.The data were collected in SPSS_15 software and the descriptive statistics (mean, standard deviation, frequency and percentage) were used to achieve the goal of Chi-square test with Fisher at the level of α = 5%.

According to the findings of this study, the prevalence of disease and response to treatment in men is higher. There is also a significant relationship between the results of OCT and drop consumption among patients. (P = < 0.005) so that in patients who were consumed drop, the amount of the retina edema and visual acuity have improved considerably compared to other patients.Based on the experiments, there was a statistically significant relationship between CRP and cortisol levels. Patients with lower CRP and cortisol responded to better treatment

According to the results, we can say that taking a drop in the treatment of patients with CSR is very effective. Prevalence and response to treatment in men is greater. It also reduces CRP and cortisol responses to treatment.